The exact date of Ahmose's reign is understandably obscure: he must have come to the throne in about 1570, 1560, or 1551 BC, and his reign must have ended in 1546, 1537, or 1527 BC. The physical examination of his mummy, which was among those rescued by Ramses IX, suggests that he lived until the age of about 35, with a reign of just over 25 years (according to Manetho).
He probably resumed the struggle against the Hyksos in about the 11th year of his reign, and this would have lasted for several years in the Delta, leading eventually to the capture of Memphis and later, Avaris.
Hyksos domination within Egypt itself had already been overwhelmed when the Egyptian troops captured the town of Sharuhen in (south-west to Palestine), which was the last citadel of the 'Asiatics'.
This final stage of the reconquest took place before the 16th year of Ahmose's reign. The most detailed surviving account of these campaigns is that left by an official at EI-Kab, Ahmose Son of Ibana, in the autobiography decorating his tomb.
The last two Hyksos Kings are not known for sure. They ruled between the 10th and 15th years of Ahmose's reign. One of those two rulers bears the name 'Aazehre' (the last king of the Fifteenth Dynasty), a name that appears on an obelisk at Tanis. The other ruler, Apophis III, was the last of the Sixteenth Dynasty Hyksos Kings, and his name appears on several monuments, including a dagger from Saqqara.
No textual source can supply the minute details on the final phase of the Hyksos rule. They were obviously no longer posing a real threat to the Thebans when Ahmose launched a campaign in the 22nd year of his reign, in which he advanced into the Djay Region of Syria-Palestine and perhaps up to the Euphrates. This would have made him the first pharaoh to have extended the frontiers this far into Western Asia.
After routing the Hyksos, Ahmose undertook the reconquest of Nubia, and Ahmose Son of Ibana also describes this campaign. A campaign that was followed by a revolt from a man called Aata, who was perhaps Nedjeh's successor as king of Kerma. However, Ahmose succeeded in restoring Egyptian control over Nubia. He may also have founded the first New Kingdom temple there, on the island of Sai to the south of Buhen, and he established Buhen as the center of administration of the province.
He assigned the commander's post at Buhen to a man called Tun, and under his successor Amenhotep I, Turi was to become the first clearly attested viceroy of Kush, although his father Zatayt may have performed this role without holding the specific title.
When Ahmose died, he left the throne to Amenhotep I, his son from Ahmose-Nefertari. In his 25th year of reign, he had achieved the liberation of Egypt and restored Egyptian links with the rest of the world, at least bringing them back to the level that had been achieved at the end of the Middle Kingdom. On this firm basis, the successors were able to build the power of their empire.
Although the body of Ahmose was found in the royal mummy cache at Deir el-Bahari, the location of his tomb remains unknown.